2-および3-オキソステロイドの酸素酸化反応(第1報)2-オキソステロイドの塩基性溶液中における酸素酸化反応

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概要

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• Treatment of the 2-oxo-5α-stereoids with potassium t-butoxide and oxygen in tbutanol gave 2,3-diketones and not 1,2-diketones as the reaction product, and also produced Δ^2-semidiones but not the Δ^1-semidiones in the ESR measurement. The substituent effect of the oxo group on the C-11 position of 25D, 5α-spirostan-2-one was not observed in the product analysis, but the ESR pattern of the Δ^2-semidione was different from that of the nonsubstituted one. 25D, 5β-Spirostan-2-one afforded the 2,3-diketone as a major product and the 1,2-diketone as a by-product under the same reaction conditions, but the principal product obtained from 25D, 5β-spirostan-2,11-dione was the peroxide (XXa) which was confirmed to be a novel transannular type compound by various ways.

• 社団法人日本薬学会の論文
• 1976-06-25

著者

• 武田 健一

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 武田 健一

  塩野義製薬(株)

• 武田 健一

  塩野義製薬株式会社研究所

• 中島 重勝

  塩野義製薬株式会社研究所

• 小中 隆盛

  塩野義製薬株式会社研究所

• 武田 健一

  Research Laboratory Shionogi & Co. Ltd.

• 武田 健一

  塩野義研

• Takeda Ken'ichi

  Shionogi Research Laboratory Shionogi & Co. Ltd.

• 小中 隆盛

  塩野義製薬 (株) 研究所

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