Bimetopyrolの抗炎症作用(第4報) : ラット肝Lysosomeに対する安定化作用

概要

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Bimetopyrol [2-methyl-4,5-bis (p-methoxyphenyl) pyrrole], a new non-steroidal antiinflammatory drug, was demonstrated to have a stabilizing effect on lysosomes from rat liver. The drug at the concentration between 1×10^<-5> and 3×10^<-4>M suppressed release of acid phosphatase from the heavy lysosome-rich fraction in neutral buffer-sucrose medium at 37°. In acid medium, however, the drug increased the enzyme release similarly as other non-steroidal anti-inflammatory drugs. The acid phosphatase activity was not affected by bimetopyrol itself under the experimental conditions employed. Some experimental conditions required for the demonstration of drug activity on lysosomal membrane were discussed.
社団法人日本薬学会の論文
1972-03-25