ミトコンドリア機能賦活作用を有する塩化レボカルニチンのラット心筋ホモジネートにおける低酸素条件下での脂肪酸及びグルコースの酸化に対する作用

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The effects of levocarnitine chloride [LC-80,(-)-(R)-(3-carboxy-2-hydroxypropyl)-trimethylammonium chloride] on the oxidation of [U-^<14>C] palmitate, [U-^<14>C] glucose and [2-^3H] glucose under hypoxic conditions in homogenates from the rat heart were investigated. LC-80 at concentrations of 0.5 and 1.0 mM caused significant and concentrationdependent increases in the depressed ^<14>CO_2 production from [U-^<14>C] palmitate or [U-^<14>C]-glucose oxidation under hypoxia up to 50 min after the addition of LC-80. In contrast, a marked increase in ^3H_2O production from [2-^8H] glucose oxidation under hypoxia was observed, and LC-80 at concentrations of 0.5 and 1.0 mM caused further significant and concentration-dependent enhancement of ^3H_2O production up to 50 min after the addition of LC-80. Moreover, LC-80 at a concentrations of 1.0 mM significantly restored the marked depression of pyruvate dehydrogenase complex activity and mitochondrial respiratory function under hypoxia. These results suggested that LC-80 has an improving effect on myocardial metabolism under ischemia by enhancing fatty acid and glucose metabolisms.
公益社団法人日本薬学会の論文
1990-03-25