ラットに気管内投与した重金属の影響(第2報)塩化カドミウムの投与後の肺の元素濃度の変化

概要

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Cadmium chloride dissolved in physiological saline (0.4 ml) was instilled intratracheally into male Wistar rats (10 weeks old ; body weight, approximately 270 g) at eight doses (40-0.313 μg Cd/rat). Concentrations of elements (calcium, copper, iron, magnesium, phosphorus, sulfur and zinc) in the lung were determined along with cadmium by inductively coupled argon plasma-atomic emission spectrometry (ICP) and/or flameless Zeeman atomic absorption spectrophotometry. The body weight decreased significantly, while the lung weight increased significantly at doses higher than 5.0 μg Cd/rat. Changes in lung weight and element concentrations suggested that lung edema was induced at a dose of as low as 2.5 μg Cd/rat. Distributions of copper and zinc in the supernatants of the lungs were determined on a gel permeation column by high performance liquid chromatography-ICP, indicating that superoxide dismutase in the lung decreased with a cadmium instillation at doses higher than 2.5 μg Cd/rat.
社団法人日本薬学会の論文
1987-10-31