ラットに気管内投与した重金属の影響(第1報)塩化カドミウムの投与量に依存した肺への取り込みと肝への移行

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Uptake and absorption of cadmium (Cd) through the airway were examined by determining the dose-dependent accumulation in the lung and its transfer to other organs after a single intratracheal instillation of cadmium chloride into rats. Male rats of the Wistar strain (10 weeks old ; body weight, 270±10 g (mean±S.D.)) were instilled with Cd dissolved in 0.4 ml saline at eight doses (0.313-40 μg Cd/rat) and killed two days later. Concentrations (μg/g tissue) and contents (μg/tissue) of Cd in the lung, liver, kidney and spleen were determined by flameless Zeeman atomic absorption spectrophotometry and/or inductively coupled argon plasma-atomic emission spectrometry (ICP). More than 90% of Cd were accumulated in the lung when the dose was lower than 2.5 μg Cd/rat, while the percentage of Cd accumulated in the lung decreased steeply at higher doses than 5 μg Cd/rat and the metal was transferred predominantly to the liver.
社団法人日本薬学会の論文
1987-10-31