フタル酸エステルの人血清及び血漿中の分解並びに血液製剤中の定量

概要

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Di 2-ethylhexyl phthalate (DEHP), mono 2-ethylhexyl phthalate (MEHP), and phthalic acid (PA) in human serum or plasma were determined by high performance liquid chromatography and serum or plasma pretreatment methods were also studied. We determined these compounds in blood products and studied what amount of these compounds in flexible bags were migrated into blood products and studied whether MEHP and PA in blood products were produced by the enzymatic action to DEHP. From the comparison of the amount of these compounds in blood products and the amount in flexible bag, it was clarified that MEHP and PA was produced by the action of lipase and esterase to DEHP. The action of esterase was greater than that of lipase and the pathway of MEHP to PA was a rate determining step of DEHP hydrolysis.
社団法人日本薬学会の論文
1984-12-31