医療用具に残留するエチレンオキサイドに関する研究 (III) : 生理食塩液を還流した血液回路から溶出されるエチレンオキサイド, エチレンクロルヒドリンおよびエチレングリコール

概要

論文の詳細を見る
Methods by gas chromatographic determination for ethylene oxide (EO), ethylene chlorohydrin (ECH) and ethylene glycol (EG) in aquous solution were investigated, and the convertions from EO to ECH and EG in various conditions were examined.The results are as follows;EO was not easily converted to ECH or EG in aquous state at 40℃ for 5 hours, resulting in only a few percent of EO convertion to ECH or EG.When saline solution was circulated into blood tubing of an artificial kindey adsorbed 150 μg/g of EO, which was made by polyvinyl chloride resin, maximum concentration of extracted EO (40μg/ml) in saline solution was obtained after 6 hours. The ratio of extracted amount of EO against the total amount of in the tubing was about 60% in this case.In case that the amount of residual EO was relatively small such as 40 μg/g, extracted EO was 3.4μg/ml and extraction ratio was remarkably reduced to 20%.When horse serum was circulated into the tubing in the same manner as the above, the investigation result suggests that a part of extracted EO is combined with protein in the serum.
日本医療機器学会の論文
1982-03-01