最近の裁判化学における薬毒物について

概要

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Carbon monoxide and pesticides are the most serious substances in poisoning from drugs and toxic substances in Japan. Organic phosphorous compounds such as sumithion, malathion, DDVP and EPN, and paraquart have been used for murder and suicide. Recently, abuse of methamphetamine and sniffing thinner have increased year by year in Japan. Radio-, enzyme and spin immunoassays were applied to microanalysis of dependence causing drugs in body fluids. Hemagglutination-inhibition test was developed as a screening test for methamphetamine in the human urine. In order to identify drugs and their metabolites in biological materials such as brain, liver, blood and urine, systematic extraction using organic solvent was carried out after β-glucuronidase treatment of the materials, fractionated extracts were purified by preparative thin-layer chromatography, and mass spectrometry was performed. Drugs and metabolites in extract were rapidly detectable by chemical ionization mass spectrometry and coloration on thin-layer chromatograms.
公益社団法人日本薬学会の論文
1982-08-31