Somatostatin Inhibits Pepsinogen Secretion without Influencing Cytosolic Free Ca^<2+> Increase Induced by Carbachol and Cholecystokinin Octapeptide in Rat Chief Cells

概要

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Gastric chief cells were isolated from the rat stomach in an attempt to identify those involved in the mechanism of action of somatostatin on pepsinogen secretion. The effects of several kinds of secretagogues on cytosolic free Ca^<2+> concentration ([Ca^<2+>]i) were examined in the rat chief cells. Carbachol and cholecystokinin octapeptide (CCK-8)markedly induced[Ca^<2+>]i increase, while histamine, gastrin I and secretin did not. Carbachol and CCK-8 also stimulated pepsinogen secretion. A similar dose-response relationship was seen in carbachol-and CCK-8-induced [Ca^<2+>]i increase and pepsinogen secretion. Somatostatin did not inhibit carbachol-or CCK-8-induced [Ca^<2+>]i increase, but did inhibit carbachol- and CCK-8-induced pepsinogen secretion by 30 and 50%, respectively.
社団法人日本薬学会の論文
1993-08-15