Direct Inhibition of Pepsinogen Secretion from Rat Gastric Chief Cells by Somatostatin

概要

論文の詳細を見る
Effects of somatostatin on pepsinogen secretion was investigated in the rat in vivo and in vitro. In the perfused rat stomach, somatostatin inhibited secretagogue-induced acid secretion in dose-dependent manner. However, effects of somatostatin on secretagogue-induced pepsinogen secretion were obscure. To clarify the effects of somatostatin on the chief cells, gastric mucosal cell were isolated by a proteolytic enzyme. Somatostain inhibited carbachol- and cholecystoknin octapeptide-induced pepsinogen secretion from dispersed gastric mucosal cells in a dose-dependent manner. Histamine-induced pepsinogen secretion, which was recovered by culturing, was also inhibited by somatostatin. These results suggest that somatostatin inhibits secretagogue-induced pepsinogen secretion directly.
社団法人日本薬学会の論文
1990-08-25