薬物投与時および潰瘍時のラット胃排出

概要

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We improved a measurement of gastric emptying in rat, in which the remaining of the gastric contents was estimated as amounts of quinaldine red mixed with the given test meal. The following results were obtained by using this method ; when chemicals were injected subcutaneously, gastric emptying was significantly faoilitated by carbamylcholine and bombesin under both anesthetized and conscious conditions, and delayed by isoproterenol under both conditions. Carbamylcholine-induced facilitation in anesthetized rats was inhibited by atropine, and isoproterenol-induced suppression in conscious rats was inhibited by propranolol. However, histamine and norepinephrine did not affect gastric emptying. Tannic acid or oxethazaine which was orally administered with the test meal, caused a suppression of gastric emptying. Acidification or neutralization of the test meal by HCl or Al (OH)_3 did not affect gastric emptying. It seems that gastric emptying was suppressed in the acetic acid gastric ulcer in the rat, but it was facilitated in the duodenal ulcer.
社団法人日本薬学会の論文
1983-02-25