Effects of Highly Purified Ethyl All-cis-5,8,11,14,17-icosapentaenoate (EPA-E) on Rabbit Platelets
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概要
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The effects of ethyl all-cis-5,8,11,14,17-icosapentaenoate (EPA-E), highly purified ethyl ester of icosapentaenoic acid (EPA), on rabbit platelets were studied. In in vitro, highly purified EPA (62.5-3000 μM) suppressed the platelet aggregation induced by collagen, arachidonic acid (AA) and adenosine diphosphate (ADP). In ex vivo, a single administration of EPA-E (300 and 1000 mg/kg, p.o.) and repeated administrations (30 and 300 mg/kg/d, p.o.) for 2 weeks showed no effects on collagen-, AA- and ADP-induced platelet aggregation. Repeated administrations (30 and 300 mg/kg/d, p.o.) for 4 weeks suppressed the collagen-induced platelet aggregation, but not the AA- and ADP-induced platelet aggregation. Repeated administrations for 4 weeks also suppressed thromboxane B_2 (TXB_2) formation induced by collagen, but a single administration and repeated administrations for 2 weeks failed to inhibit TXB_2 formation. The EPA level in the platelet phospholipids increased slightly with a single administration, and increased markedly with repeated administrations for 2 and 4 weeks. The AA level in the phospholipids showed practically no changes with a single and repeated administrations. These results suggested that highly purified EPA-E could reduce platelet aggregability by the change of the EPA level in the platelet phospholipids and should allow for a reasonable period of administration.
- 公益社団法人日本薬学会の論文
- 1993-04-15
著者
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佐藤 正巳
持田製薬(株)総合研究所
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溝田 雅洋
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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佐藤 正巳
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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甲木 由紀夫
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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福原 薫
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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河野 浩之
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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浜田 悦昌
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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国広 靖之
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
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浜田 悦昌
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
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溝田 雅洋
持田製薬 富士中研
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甲木 由紀夫
持田製薬 安全性研
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甲木 由紀夫
持田製薬株式会社総合研究所
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福原 薫
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
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国広 靖之
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
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