Lack of Stereoselectivity in Rat Liver Peroxisomal Enzyme Induction by Optically Active Phenoxyacetic Acids
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概要
- 論文の詳細を見る
To ascertain if there is stereoselectivity in peroxisomal proliferation induced by chiral peroxisome proliferators, induction by stereoisomers of 2-methyl-4'-chlorophenoxyacetic acid and 2-methyl-2-(2', 4'-dichlorophenoxy)acetic acid were studied in rat in vivo and in vitro with isolated rat hepatocytes. No significant differences in the inducing potencies of the stereoisomers of the above two phenoxyacetic acid derivatives were found for cyanide-insensitive fatty acyl-CoA oxidizing system, fatty acyl-CoA oxidase, carnitine acetyltransferase or carnitine palmitoyltransferase. There was also no significant difference in the degree of hepatomegaly or lipid-lowering effect between the isomers. The findings with cultured rat hepatocytes agreed with those of the studies in vivo.
- 1993-01-15
著者
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渡辺 隆史
東京薬学大学薬学部臨床生化学教室
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渡辺 隆史
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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須賀 哲弥
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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山田 純司
東薬大・薬
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鯉渕 康全
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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山田 純司
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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須賀 哲弥
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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鯉渕 康全
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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