Effects of Phytol, a Branched, Long-Chain Aliphatic Alcohol, on Biochemical Values and on Hepatic Peroxisomal Enzymes of Rats

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The effects of phytol on biochemical values (triglyceride and cholesterol levels of liver and serum, body weight gain and liver weight), and peroxisomal enzyme activities were investigated in rats. The rats were given phytol orally at the dose of 200 or 500 mg/kg body weight daily for 3 weeks. The triglyceride and cholesterol levels of the serum of the rats treated with phytol at 500mg/kg decreased by 32 and 35% respectively, while no influence on body weight gain or liver weight was observed. Fatty acyl-CoA oxidase activity and catalase activity in the livers of treated rats were increased by 29 and 20% at 200mg/kg, and by 36 and 44% at 500mg/kg, respectively. D-Amino acid oxidase activity was also increased by 54% (at 200mg/kg) and 85% (at 500mg/kg) in treated animals, but the activity of another peroxisomal enzyme, urate oxidase, did not change. On sucrose density gradient centrifugation of the light mitochondrial fractions prepared from the livers of control and treated rats, similar distribution patterns were observed in both samples, but the activities of catalase and fatty acyl-CoA oxidase of peroxisomal fraction of the treated (500mg/kg) group were increased by 68 and 45%, respectively. These results suggest that phytol might enhance peroxisomal β-oxidation and also induce some peroxisomal enzymes, causing change of peroxisomal enzyme compositions.
公益社団法人日本薬学会の論文
1983-08-25