Peroxisomal Enzyme Activities in the Liver of Overtly Diabetic Non-obese Diabetic Mouse
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概要
- 論文の詳細を見る
Enzyme activities of hepatic peroxisomes were examined in spontaneously diabetic non-obese diabetic (NOD) mice. Peroxisomal fatty acid β-oxidation activity in the NOD diabetic mouse was the same as that of the ICR mouse. Sodium glutamate-induced obesity did not affect peroxisomal enzymes. The results indicate that peroxisomal β-oxidation does not increase in the insulin-deficient mouse. Furthermore, considering that the onset of diabetes in the NOD mouse is around 13 weeks after birth, these findings suggest that hepatic peroxisomal β-oxidation is utilized mainly in the acute state, not in the chronic state, in order to obtain adenosine triphophate urgently for cellular demands.
- 公益社団法人日本薬学会の論文
- 1986-11-25
著者
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堀江 修一
女子栄養大
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渡辺 隆史
東京薬学大学薬学部臨床生化学教室
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渡辺 隆史
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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須賀 哲弥
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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栩野 義博
Shionogi Research Laboratories Shinogi & Co. Ltd.
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堀江 修一
Department of Clinical Biochemistry, Tokyo College of Pharmacy
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須賀 哲弥
Department Of Clinical Biochemistry Tokyo College Of Pharmacy
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