A Novel Anti-Allergic Drug, Betotastine Besilate, Suppresses Interleukin-5 Production by Human Peripheral Blood Mononuclear Cells

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概要

• 論文の詳細を見る

• The effect of a novel anti-allergic drug, betotastine besilate (betotasitine) on intertleukin (IL)-5 production by human peripheral blood mononuclear cells (PBMC) was investigated. PBMC of Dermatophagoides farinae extract (Df)-sensitive donors produced IL-5 and showed a proliferative responce upon stimulation with relevant antigen (10μg/ml). Df-induced IL-5 production by PBMC was significantly inhibited by betotastine at 10 and 100 μM. Betotastine also suppressed proliferation of PBMC with less potency. The effect of betotastine on IL-5 production was enhanced and significant even at 0.1 μM when the drug was added 120 min before antigen stimulation. Ketotifen and cetirizine also inhibited IL-5 production, but the effects of these drugs were significant only at 100 μM. These findings indicate that the suppression of IL-5 production may be involved in the anti-allergic effect of betotastine.

• 公益社団法人日本薬学会の論文
• 1998-04-15

著者

• KIKKAWA Hideo

  Lead Optimization Research Laboratory, Tanabe Seiyaku, Co., Ltd.

• NAITO Kazuaki

  Lead Optimization Research Laboratory, Tanabe Seiyaku, Co., Ltd.

• IKEZAWA Katsuo

  Lead Optimization Research Laboratory, Tanabe Seiyaku, Co., Ltd.

• KAMINUMA Osamu

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Ogawa Koji

  Clinical Research Center For Allergy And Rheumatology National Sagamihara Hospital

• Kikkawa H

  Discovery Research Laboratory Tanabe Seiyaku Co.

• Naito K

  Discovery Research Laboratory Tanabe Seiyaku Co.

• Naito Kazuaki

  Lead Optimization Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co. Ltd.

• Ikezawa K

  Discovery Research Laboratory Tanabe Seiyaku Co.

• Kaminuma Osamu

  Clinical Research Center For Allergy And Rheumatology National Sagamihara Hospital

• Kaminuma O

  国立相模原病院

• Ogawa Koji

  Research Institute For Higher Education Programs Hokkaido Tokai University

• Oka K

  Research Institute For Advanced Science And Technology (riast) Osaka Prefecture University

• OGAWA Koji

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• KIKUCHI Matsuo

  Pharmaceutical Development Research Laboratory, Tanabe Seiyaku Co., Ltd.,

• Kikuchi M

  Pharmaceutical Development Research Laboratory Tanabe Seiyaku Co. Ltd.

• Kikuchi Matsuo

  Pharmaceutical Development Research Laboratory

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