Inhibitory Effect of a Novel Phosphodiesterase IV Inhibitor, T-440, on Antigen- and Chemical Mediator-Induced Bronchoconstrictions in Guinea Pigs In Vivo

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概要

• 論文の詳細を見る
• 1996-09-01

著者

• Matsubara Shigeki

  Lead Optimization Research Laboratory Tanabe Seiyaku Co. Ltd.

• KIKKAWA Hideo

  Lead Optimization Research Laboratory, Tanabe Seiyaku, Co., Ltd.

• IKEZAWA Katsuo

  Lead Optimization Research Laboratory, Tanabe Seiyaku, Co., Ltd.

• KAMINUMA Osamu

  Lead Optimization Research Laboratory, Tanabe Seiyaku Co., Ltd.

• Kikkawa H

  Discovery Research Laboratory Tanabe Seiyaku Co.

• Suko Matsunobu

  Department Of Medicine And Physical Therapy University Of Tokyo Faculty Of Medicine

• Ikezawa K

  Discovery Research Laboratory Tanabe Seiyaku Co.

• Kaminuma Osamu

  Clinical Research Center For Allergy And Rheumatology National Sagamihara Hospital

• Kaminuma O

  国立相模原病院

関連論文

• Difference in Inhibitory Effects of Dexamethasone and Cyclosporin A on Sephadex Bead-Induced Airway Hyperresponsiveness and Inflammation in Rats
• Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors
• Inhibitory Effect of a Novel Phosphodiesterase IV Inhibitor, T-440, on Antigen- and Chemical Mediator-Induced Bronchoconstrictions in Guinea Pigs In Vivo
• Importance of Impairment of the Airway Epithelium for Ozone-Induced Airway Hyperresponsiveness in Guinea Pigs
• Bronchial Anti-spasmogenic Effects and Selectivity of T-440,Phosphodiesterase Type 4 Inhibitor, in the Dog
• Correlation between eosinophilia induced by CD4^+ T cells and bronchial hyper-responsiveness
• A critical role of IL-2 for the production and gene transcription of IL-5 in allergen-specific human T cell clones
• Cloning and Expression of cDNA Coding for the Major House Dust Mite Allergen Der f II in Escherichia coli(Biological Chemistry)
• Difference among Angiotensin - Converting Enzyme Inhibitors in Potentiating Effects on Bradykinin - Induced Microvascular Leakage in Guinea Pig Airways
• Selective suppression of T_h2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists
• Transcriptional Regulation of IL-5 Gene by Nontransformed Human T Cells Through the Proximal Promoter Element
• A novel hypothesis for the gene expression for the control of atopic and other hereditary diseases
• IL-5 production by CD4^+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A
• A Novel Anti-Allergic Drug, Betotastine Besilate, Suppresses Interleukin-5 Production by Human Peripheral Blood Mononuclear Cells
• PHARMACOLOGICAL EFFECTS OF NICERGOLINE AND ITS METABOLITES, DECOMPOSITION PRODUCTS AND IMPURITIES IN ANIMALS

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