Involvement of calciseptine-Sensitive Calcium Channels in the Evoked Acetylcholine Release from Electric Organ Synaptosomes
スポンサーリンク
概要
- 論文の詳細を見る
The high K^+ -evoked release of acetylcholine (ACh) from electric organ synaptosomes isolated from the Japanese marine ray, Narke japonica, was strongly inhibited by dihydropyridines at micromolar concentrations. However, this inhibition seems to be a non-specific effect sine the agonist (-)-Bay K 8644 also had inhibitory effects. Calciseptine, a peptide toxin specific for L-type Ca channels, inhibited to a lesser extent the evoked acetylcholine release : the maximum inhibition was about 20%. This finding is in accord with our data (Tokumaru et al., J. Neurochem., 65,831 (1995)) regarding inhibition by a monoclonal antibody against the α_2δ-subunit of the L-type Ca channel and provides evidence for the involvement of an L-type-like Ca channel in ACh release in addition to ω-conotoxin GVIA-sensitive N-type and ω-agatoxin IVA-sensitive P-type Ca channels.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
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Kirino Yutaka
Faculty Of Pharmaceutical Sciences Kyushu University:faculty Of Pharmaceutical Sciences University O
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Kirino Yutaka
Faculty Of Pharmaceutical Sciences Kyushu University
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HIRASHIMA Naohide
Faculty of Pharmaceutical Sciences, Nagoya City University
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YAMAMOTO Haruhiko
Faculty of Agriculture, Yamaguchi University
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TOKUMARU Hiroshi
Faculty of Pharmaceutical Sciences, The University of Tokyo
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SATOH Yasushi
Faculty of Pharmaceutical Sciences, The University of Tokyo
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SHOJAKU Suzuyo
Faculty of Pharmaceutical Sciences, Kyushu University
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Shojaku Suzuyo
Faculty Of Pharmaceutical Sciences Kyushu University
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Yamamoto Haruhiko
Faculty Of Agriculture Yamaguchi University
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Hirashima N
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Hirashima Naohide
Grad. Sch. Pharmaceut. Sci. Nagoya City Univ.
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Hirashima Naohide
Faculty Of Pharmaceutical Sciences Kyushu University
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Kirino Yutaka
Faculty Of Pharmaceutical Sciences At Kagawa Campus Tokushima Bunri University
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Yamamoto Haruhiko
Faculty Of Science Kanagawa University
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