The Inhibitory Effect of an Extract of Sanguisorba officinalis L. on Ultraviolet B-Induced Pigmentation via the Suppression of Endothelin-Concerting Enzyme-1α

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Endothelin-1(ET-1)has been reported to be expressed in human epidermis at both the gene and protein levels. ET-1 plays a pivotal role in ultraviolet B(UVB)-induced pigmentation due to its accentuated secretion after UVB irradiation and its function as a mitogen and asa melanogenfor human melanocytes. We have recently found that endothelin-converting enzyme(ECE)-1α plays a constitutive role in the secretion of ET-1 by human keratinocytes and that an extract of Sanguisorba officinalis L. inhibits ECE activity in human endothelial cells, which predominantly rexpress ECE-1α. In this report, to clarify the potential use of this botanical extract as a whitening agent, we eca, omed whether this extract inhibits UVB-induced pigmentation in vivo. When this extract was applied to human keratinocytes after UVB irradiation, secretion of ET-1 by those cells was reduced, and this was accompanied by a concomitant increase in the secretion of inactive precursor Big endothelin-1. When hairless mice were exposed to UVB light and were treated with the extract, it suppressed the induction of ET-1 in the UVB-irradiated epidermis. In the course of UVB-induced pigmentation of brownish guinea pig skin, this extract signficantly diminished pigmentation in UVB-exposed areas. These findings indicate that ECE-1α in keratinocytes plays a pivotal role in the induction of pigmentation following UVB irradiation and that an extract of S. officinalis, which inhibits ET-1 production in human keratinocytes, is a good ingredient for a whitening agent.
公益社団法人日本薬学会の論文
2001-06-01

The Inhibitory Effect of an Extract of Sanguisorba officinalis L. on Ultraviolet B-Induced Pigmentation via the Suppression of Endothelin-Concerting Enzyme-1α

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