The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation(Miscellaneous)
スポンサーリンク
概要
- 論文の詳細を見る
It has been reported that application of sunscreens prevents the photoaging of skin in animal models and in humans. We irradiated the dorsal skin of hairless mice with ultraviolet-A (UVA), and investigated the effects of sunscreens on skin elastase activity and on skin properties. Six-week-old female HR/ICR hairless mice were used in these experiments. After being treated with either a UVA sunscreen (also containing ultraviolet-B (UVB) sunscreen to eliminate any slight UVB in the UVA lamps; Protection Factor of UVA (PFA)=6, Sun Protection Factor (SPF)=20) or a vehicle, the dorsal skins of mice were irradiated with the UVA lamps at 22.3J/cm^2/d, 5 times a week. At the end of 15 weeks skin properties were evaluated and elastase activities were measured. In the vehicle control group, UVA irradiation increased the brightness and yellowing of the skin, decreased the water content of the stratum corneum, increased skin thickness, decreased skin elasticity, increased skin elastase activity, and decreased the ability of the skin to recover in a pinch test, as compared to an unirradiated group. All these differences were statistically significant. In the UVA sunscreen group, both the UVA induced skin damage and the increase in skin elastase activity were significantly inhibited, as compared to the vehicle group. However, as compared to the unirradiated group, skin elastase activity was significantly increased and immediate extensibility of skin (Ue) was significantly decreased, thereby indicating that the UVA sunscreen did not prevent photoaging to the same level as the unirradiated group. These results suggest the partial efficacy of the topical photoprotection from UVA by the sunscreen in inhibiting elastase activation, and also suggest the possibility of reducing photoaging.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
-
Fujimura Tsutomu
花王生物科学研究所
-
Fujimura Tsutomu
Biological Science Laboratories Kao Corporation
-
Sugiyama-nakagiri Yoriko
花王生物科学研究所
-
Kitahara Takashi
花王生物科学研究所
-
Tsukahara Kazue
Global R&d Biological Science Kao Corporation
-
Fujimura Tsutomu
Second Tokushima Factory Otsuka Pharmaceutical Co. Ltd.
-
HOTTA Mitsuyuki
Biological Science Laboratories, Kao Corporation
-
KITAHARA Takashi
Biological Science Laboratories, Kao Corporation
-
MORIWAKI Shigeru
Biological Science Laboratories, Kao Corporation
-
TAKEMA Yoshinori
Biological Science Laboratories, Kao Corporation
-
TSUKAHARA Kazue
Biological Science Laboratories, Kao Corporation
-
SUGIYAMA Yoriko
Biological Science Laboratories, Kao Corporation
-
SUGAWARA Satoshi
Skin Care Research Laboratories, Kao Corporation
-
KITAHARA Takashi
Kao Corporation Biological Science Laboratories
-
Moriwaki Shigeru
Global R&d Biological Science Kao Corporation
-
Hotta Mitsuyuki
Global R&d Biological Science Kao Corporation
-
Hotta Mitsuyuki
Biological Science Laboratories Kao Corporation
-
Tsukahara Kazue
Biological Science Laboratories Kao Corporation
-
Sugiyama Yoriko
Biological Science Laboratories Kao Corporation
-
Sugawara Satoshi
Skin Care Research Laboratories Kao Corporation
-
Takema Yoshinori
Global R&d Biological Science Kao Corporation
-
Takema Yoshinori
Biological Science Laboratories Kao Corporation
-
Kitahara Takashi
Biological Science Laboratories Kao Corporation
関連論文
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs
- Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
- Partial Hepatectomy Enhances Polyethylenimine-Mediated Plasmid DNA Delivery
- Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus
- Sensitive and Real-Time Method for Evaluating Corneal Barrier Considering Tear Flow
- A Practical Synthesis of (S)-(-)-Nadifloxacin : Novel Acid-Catalyzed Racemization of Tetrahydroquinaldine Derivative
- Loss of skin elasticity precedes to rapid increase of wrinkle levels
- Crucial role of fibroblast integrins α2 and β1 in maintaining the structural and mechanical properties of the skin
- Horse Chestnut Extract Induces Contraction Force Generation in Fibroblasts through Activation of Rho/Rho Kinase(Molecular and Cell Biology)
- The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation(Miscellaneous)
- Inhibitory Effect of an Extract of Sanguisorba officinalis L.on Ultraviolet-B-Induced Photodamage of Rat Skin
- Epidermal change can alter mechanical properties of hairless mouse skin topically treated with 1α,25-dihydroxyvitamin D_3
- Fucoidan Is the Active Component of Fucus vesiculosus that Promotes Contraction of Fibroblast-Populated Collagen Gels
- Effects of UVB on the Skin of Ovariectomized Animals
- Effects of Natural Product Extracts on Contraction and Mechanical Properties of Fibroblast Populated Collagen Gel
- Ethnic differences in the structural properties of facial skin
- Age-related changes in the epidermal architecture around facial pores
- Biodistribution and Pharmacokinetics of O-Palmitoyl Tilisolol, a Lipophilic Prodrug of Tilisolol, after Intravenous Administration in Rats
- trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor β2 (TGF-β2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes(Pharmacology)
- Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women
- Keratin alterations could be an early event of wrinkle formation
- Evaluation of Newly Developed Oxygen Meters with Multi-Channels and Disposable Oxygen Electrode Sensors for Antimicrobial Susceptibility Testing
- Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids
- INTESTINAL ABSORPTION AND METABOLISM OF HOMOURSO DEOXYCHOLIC ACID IN RATS
- Inhibitory Mechanism of an Extract of Althaea officinalis L.on Endothelin-1-Induced Melanocyte Activation
- The Inhibitory Effect of an Extract of Sanguisorba officinalis L. on Ultraviolet B-Induced Pigmentation via the Suppression of Endothelin-Concerting Enzyme-1α
- A Study of the Mother-Infant Relationships of Chimpanzees (Pan troglodytes) during the First Four Years of Infancy in Tama Zoological Park
- The relationship between quantitative changes in collagen and formation of wrinkles on hairless mouse skin after chronic UV irradiation
- Age-related discontinuous changes in the in vivo fluorescence of human facial skin