trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor β2 (TGF-β2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
trans-3,4'-Dimethyl-3-hydroxyflavanone (t-flavanone) is a synthetic compound with hair growth enhancing activity that is effective against male pattern alopecia. t-Flavanone was designed as a derivative of astilbin, the active hair growth enhancing component of Hypericum perforatum extracts. This study was designed to elucidate the mechanism of hair growth enhancement by t-flavanone. We investigated the effects of t-flavanone on transforming growth factor β (TGF-β), a known catagen-inducing factor induced in hair papilla cells by male hormone. When t-flavanone was added to cocultures of human hair papilla cells and human keratinocytes, there was no change in the total level of TGF-β2. However, levels of active TGF-β2 were reduced, suggesting the involvement of t-flavanone in the activation pathway of TGF-β2. In order to investigate the effects of t-flavanone on TGF-β2 activation by human keratinocytes, we evaluated the level of active TGF-β2 converted from the inactive form in t-flavanone-treated human keratinocytes. The amount of active TGF-β2 was reduced compared with controls suggesting that t-flavanone suppresses the TGF-β2 activation cascade in human keratinocytes. We then examined the activity of urokinase-type plasminogen activator (uPA), the rate-limiting enzyme in the TGF-β2 activation cascade, in t-flavanone-treated human keratinocytes. We found that t-flavanone reduces uPA activity on the keratinocyte surface. t-Flavanone is a hair growth enhancing component that has a novel mechanism of action which suppresses TGF-β2 activation, and thereby is expected to have therapeutic effects on other types of alopecia in addition to male pattern alopecia.
- 公益社団法人日本薬学会の論文
- 2008-03-01
著者
-
Kitahara Takashi
花王生物科学研究所
-
Tsukahara Kazue
Global R&d Biological Science Kao Corporation
-
KITAHARA Takashi
Kao Corporation Biological Science Laboratories
-
SASAJIMA Michiyo
Global R&D, Biological Science, Kao Corporation
-
MORIWAKI Shigeru
Global R&D, Biological Science, Kao Corporation
-
HOTTA Mitsuyuki
Global R&D, Biological Science, Kao Corporation
-
KITAHARA Takashi
Global R&D, Biological Science, Kao Corporation
-
TAKEMA Yoshinori
Global R&D, Biological Science, Kao Corporation
-
Moriwaki Shigeru
Global R&d Biological Science Kao Corporation
-
Hotta Mitsuyuki
Global R&d Biological Science Kao Corporation
-
Tsukahara Kazue
Biological Science Laboratories Kao Corporation
-
Sasajima Michiyo
Global R&d Biological Science Kao Corporation
-
Takema Yoshinori
Global R&d Biological Science Kao Corporation
-
Kitahara Takashi
Biological Science Laboratories Kao Corporation
関連論文
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Multiple Anti-glaucoma Drugs
- Influence of murine hepatitis induced by D-(+)-galactosamine hydrochloride and lipopolysaccharide on gene expression of polyethylenimine/plasmid DNA polyplex
- Ocular Pharmacokinetic/Pharmacodynamic Modeling for Timolol in Rabbits Using a Telemetry System
- Partial Hepatectomy Enhances Polyethylenimine-Mediated Plasmid DNA Delivery
- Antimicrobial Activity of Saturated Fatty Acids and Fatty Amines against Methicillin-Resistant Staphylococcus aureus
- Sensitive and Real-Time Method for Evaluating Corneal Barrier Considering Tear Flow
- Loss of skin elasticity precedes to rapid increase of wrinkle levels
- Crucial role of fibroblast integrins α2 and β1 in maintaining the structural and mechanical properties of the skin
- Horse Chestnut Extract Induces Contraction Force Generation in Fibroblasts through Activation of Rho/Rho Kinase(Molecular and Cell Biology)
- The Effect of Sunscreen on Skin Elastase Activity Induced by Ultraviolet-A Irradiation(Miscellaneous)
- Inhibitory Effect of an Extract of Sanguisorba officinalis L.on Ultraviolet-B-Induced Photodamage of Rat Skin
- Epidermal change can alter mechanical properties of hairless mouse skin topically treated with 1α,25-dihydroxyvitamin D_3
- Fucoidan Is the Active Component of Fucus vesiculosus that Promotes Contraction of Fibroblast-Populated Collagen Gels
- Effects of UVB on the Skin of Ovariectomized Animals
- Effects of Natural Product Extracts on Contraction and Mechanical Properties of Fibroblast Populated Collagen Gel
- Ethnic differences in the structural properties of facial skin
- Age-related changes in the epidermal architecture around facial pores
- Biodistribution and Pharmacokinetics of O-Palmitoyl Tilisolol, a Lipophilic Prodrug of Tilisolol, after Intravenous Administration in Rats
- trans-3,4'-Dimethyl-3-hydroxyflavanone, a Hair Growth Enhancing Active Component, Decreases Active Transforming Growth Factor β2 (TGF-β2) through Control of Urokinase-Type Plasminogen Activator (uPA) on the Surface of Keratinocytes(Pharmacology)
- Comparison of age-related changes in facial wrinkles and sagging in the skin of Japanese, Chinese and Thai women
- Evaluation of Newly Developed Oxygen Meters with Multi-Channels and Disposable Oxygen Electrode Sensors for Antimicrobial Susceptibility Testing
- INTESTINAL ABSORPTION AND METABOLISM OF HOMOURSO DEOXYCHOLIC ACID IN RATS
- Inhibitory Mechanism of an Extract of Althaea officinalis L.on Endothelin-1-Induced Melanocyte Activation
- The Inhibitory Effect of an Extract of Sanguisorba officinalis L. on Ultraviolet B-Induced Pigmentation via the Suppression of Endothelin-Concerting Enzyme-1α
- A Study of the Mother-Infant Relationships of Chimpanzees (Pan troglodytes) during the First Four Years of Infancy in Tama Zoological Park