INTESTINAL ABSORPTION AND METABOLISM OF HOMOURSO DEOXYCHOLIC ACID IN RATS
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概要
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Intestinal absorption, hepatic biotransformation and intestinal bacterial modification of the C_<25> homolog of ursodeoxycholic acid, homoursodeoxycholic acid, and its glycine conjugate, glycohomoursodeoxycholic acid, were studied in rats. Homoursodeoxycholic acid, like ursodeoxycholic acid, was efficiently absorbed from the intestine and rapidly excreted into the bile. Most (>95%) of the absorbed homoursodeoxycholic acid was found to undergo β-oxidation to form two C_<23> bile acids, norursodeoxycholic acid and nor-β-muricholic acid during passage through the liver. Bacterial modification of homoursodeoxycholic acid was very similar to that of ursodeoxycholic acid. In the rat intestinal tract, glycohomoursodexycholic acid was deconjugated to form unconjugated homoursodeoxycholic acid which was then 7β-dehydroxylated to form homolithocholic acid.
- 公益社団法人日本薬学会の論文
著者
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KURAMOTO Taiju
Institute ofPharmaceutical Sciences, Hiroshima University, School ofMedicine
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HOSHITA Takahiko
Institute of Pharmaceutical Sciences, Faculty of Medicine, Hiroshima University
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Kuramoto Taiju
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Kawamoto Keiko
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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MORIWAKI SHIGERU
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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Moriwaki Shigeru
Global R&d Biological Science Kao Corporation
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Hoshita Takahiko
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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