Hypocholesteriolemic Effect of Bile Acid Sulfonate Analogs in Hamsters
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概要
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We studied the effects of bile acid sulfonate analogs, namely, 3α, 7α, 12α-trihydroxy-5β-cholane-24-sulfonate(C-sul), 3α, 7α-trihydroxy-5β-cholane-24-sulfonate(CDC-sul), and 3α, 7β-dihydroxy-5β-cholane-24-sulfonate(UDC-sul), on serum and liver cholesterol levels, cholesterol 7α-hydroxylase activity, and biliary bile acid composition in hamsters fed cholesterol. Of the three analogs studied, UDC-sul slightly but sifnificantly decreased free, esterified, and total cholesterol concentrations inthe serum. UDC-sul and CDC-sul reduced liver total cholesterol levels by 25% and 18%, respectively, particularly in the esterigied cholesterol fracition. Analysis of biliary bile acids showed the presence of the administered analogs, indicating that sulfonate analogs efficiently participate in eneterohepatic cycling. The proportion of cholic acid was increased in all groups fed sulfonate analogs, but the ratio of glycine to taurine conjugated bile acids(G/T)was elevated only in UDC-sul feeding hamsters. There was no significant change in cholesterol 7α-hydroxylase activity in hamsters fed C-sul or CDC-sul, while UDC-sul slightly stimulated the enzyme activity compared to the control. The UDC-sul induced decrease in serum and liver cholesterol concentrations may be secondary to enhanced bile acid synthesis. This is supported by the increased cholesterol 7α-hydroxylase activity and elevated G/T ratio in biliary bile acids observed following UDC-sul administration.
- 社団法人日本薬学会の論文
- 2001-03-01
著者
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Une Mizuho
Institute Ofpharmaceutical Sciences Hiroshima University School Ofmedicine
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Une Mizuho
広島大学 医歯薬総合研究 薬効解析科学
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Une Mizuho
九州大学 第1外科
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Une Mizuho
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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FUJIMURA Kingo
Institute of Pharmaceutical Sciences, Hiroshima University, School ofMedicine
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KURAMOTO Taiju
Institute ofPharmaceutical Sciences, Hiroshima University, School ofMedicine
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KIM Hyun-Guell
Institute of Pharmaveutical Sciences, Hiroshima University School of Medicine and Department of Bioc
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NOSHIRO Mitsuhide
Institute of Pharmaveutical Sciences, Hiroshima University School of Medicine and Department of Bioc
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Kuramoto T
Hiroshima Univ. School Of Medicine Hiroshima Jpn
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Kuramoto Taiju
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Noshiro Mitsuhide
Institute Of Pharmaveutical Sciences Hiroshima University School Of Medicine And Department Of Bioch
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Fujimura Kingo
Institute Of Pharmaceutical Sciences Hiroshima University School Ofmedicine
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Kim Hyun-guell
Institute Of Pharmaveutical Sciences Hiroshima University School Of Medicine And Department Of Bioch
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