CONTRIBUTION OF RENAL ACTIVE SECRETION IN RENAL EXCRETION OF N^4-ACETYLSULFAMONOMETHOXINE IN CONSCIOUS PIGS
スポンサーリンク
概要
- 論文の詳細を見る
The contribution of renal active tubular secretion of N^4-acetylsulfamonomethoxine (AcSMM) in renal excretion was examined using 3 conscious pigs with permanent ureter cannulae. AcSMM was the main metabolite of sulfamonomethoxine (SMM) in pigs. When AcSMM (100 mg/kg) was intravenously injected, the renal clearance of AcSMM increased with the decrease of AcSMM plasma concentration. Michaelis-Menten kinetics was demonstrated in the renal excretion of AcSMM. It can be concluded that AcSMM is mostly excreted through active tubular secretion. The decrease of renal clearance of AcSMM may be thought as the causal factor of nonlinear plasma kinetics of SMM in pig.
- 公益社団法人日本薬学会の論文
著者
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TANAKA Nobue
Superconductivity Research Laboratory, International Superconductivity Technology Center
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Tanaka N
Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol
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SHIMODA MINORU
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Techn
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KOKUE EIICHI
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Techn
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TANAKA NOBUE
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Techn
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HAYAMA TOYOAKI
Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Techn
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Kokue Eiichi
Labo. Of Veterinary Pharmacol. Fac. Of Agriculture Tokyo Univ. Of Agriculture And Technology
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Kokue Eiichi
Department Of Veterinary Medicine Tokyo University Of Agriculture And Technology
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Hayama T
Tokyo Univ. Agriculture And Technology Tokyo Jpn
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Hayama Toyoaki
Laboratory Of Veterinary Pharmacology Faculty Of Agriculture Tokyo University Of Agriculture And Tec
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Hayama Toyoaki
Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol
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Shimoda Minoru
Laboratory Of Veterinary Pharmacology Faculty Of Agriculture Tokyo University Of Agriculture And Tec
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Shimoda Minoru
Department Of Veterinary Medicine Faculty Of Agriculture Tokyo University Of Agriculture And Technol
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