Studies on Organometallic Compounds. III. Reaction of Trimethylstannylazines with Acyl Chlorides. A Novel C-C Bond Formation of Pyridine Nuclei
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Introduction of an acyl group at the α-, β-, and γ-positions of pyridine nuclei was accomplished. 2-Trimethylstannyl-pyridine and -quinoline and 1-trimethylstannyliso-quinoline directly reacted with various acyl chlorides to give the corresponding 2-pyridyl, 2-quinolyl, and 1-isoquinolyl ketones, respectively. Reaction of 3-trimethylstannyl-pyridine, -quinoline, and -isoquinoline with acyl chlorides proceeded smoothly under catalysis by PdCl_2 or PdCl_2 (PPh_3)_2 to afford the corresponding ketones in good yields. Similarly, 4-pyridyl, -quinolyl, and -isoquinolyl ketones were prepared from the corresponding 4-trimethylstannyl derivatives and acyl chlorides.
- 公益社団法人日本薬学会の論文
- 1982-06-25
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