1,3-Oxazines and Related Compounds. VI. Synthesis and Some Reactions of 2,6-Disubstituted 4H-1,3-Thiazin-4-ones
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概要
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Various of 2,6-disubstituted 4H-1,3-thiazin-4-ones (5) were synthesized by successive treatment of N-acylacetylcarboxamides with acid (such as 70% perchloric acid or fluorosulfonic acid) and hydrogen sulfide. Reactions of 5 were investigated ; ammonolysis with ethanolic ammonia gave the corresponding pyrimidin-4-ones; hydrolysis of 2-alkyl-1,3-thiazine derivatives yielded ring-opened N-acyl-β-mercaptocrotonamides ; reduction with NaBH_4 or LiAlH_4 afforded 3,4-dihydro-2H-1,3-thiazin-4-one derivatives.
- 社団法人日本薬学会の論文
- 1983-06-25
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