Studies on Furan Derivatives. X. Preparation of 2-Substituted 3-(5-Nitro-2-furyl) quinoxaline 1,4-Dioxides and Determination of Their Antibacterial Activity
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概要
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2-Substituted 3-(5-nitro-2-furyl) quinoxaline 1,4-dioxides (Va-g) were prepared by the reaction of benzofurazan 1-oxide with α-aryl- or α-(2-furyl)-β-(5-nitro-2-furyl)-vinylamines and aryl or 2-furyl 5-nitro-2-furfuryl ketones. It was found that primary enamines, as well as tertiary enamines, are useful in this reaction. One-pot synthesis of 2-(2-furyl)-3-(5-nitro-2-furyl) quinoxaline 1,4-dioxide (Va) from 2-[β-(5-nitro-2-furyl) ethynyl] furan was examined, and afforded Va in 11% yield. Compounds Va-g were subjected to antibacterial activity tests and some of them showed activity at 6.25-25μg/ml (minimal inhibitory concentration).
- 社団法人日本薬学会の論文
- 1981-01-25
著者
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田中 昭
Faculty Of Pharmaceutical Sciences Josai University
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田中 昭
Faculty Of Engineering And Design Kyoto Institute Of Technology
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臼井 敏直
Faculty of Pharmaceutical Sciences, Josai University
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臼井 敏直
Faculty Of Pharmaceutical Sciences Josai University
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