Resonance Transfer of Excitation Energy between Non-steroidal Anti-inflammatory Drugs and Aromatic Amino Acids
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概要
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The critical distance, R_0,which is the rate parameter for the transfer of excitation energy by resonance between aromatic amino acids and 14 kinds of non-steroidal anti-inflammatory drugs or some of other aromatic compounds was calculated. The rank correlation between the R_0 values and anti-inflammatory activity were found to be significant, and the activity of various nonsteroidal anti-inflammatory drugs were illustrated uniformly at a molecular level. Finally, a possibility of formation of electronic excited state of aromatic amino acid residues in living cell was discussed.
- 公益社団法人日本薬学会の論文
- 1970-01-25
著者
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富岡 穂一
Research Laboratory, Chugai Pharmaceutical Co., Ltd.
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畑 俊一
Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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水野 光司
中外製薬新薬研究所
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富岡 穂一
中外製薬株式会社綜合研究所
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水野 光司
Research Laboratories, Chugai Pharmaceutical Co., Ltd., Takada, Toshima-ku, Tokyo
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畑 俊一
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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富岡 穂一
Research Laboratory Chugai Pharmaceutical Co. Ltd.
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水野 光司
Research Laboratories Chugai Pharmaceutical Co. Ltd.
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