Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). III. 6,7-Dihydrodiol
スポンサーリンク
概要
- 論文の詳細を見る
6,7-Dihydrodiol (1) has been isolated as a principal metabolite of ibudilast. We determined the structural formula of this compound (1) and made the stereochemical behavior is solution clear by the results of nuclear magnetic resonance (NMR) spectra. From these results, 6,7-dihydrodiol (1) exists as the equilibrium mixture of diastereomers and this equilibrium is influenced by the polarity of the solvent. It is concluded that 6,7-dihydrodiol (1) exists mainly as a cis quasi-equatorial-quasi-axial conformation (7-OH quasi-axial) in a non- or weak-polar solvent and mainly exists as a trans quasi-diaxial conformation in a polar solvent.
- 社団法人日本薬学会の論文
- 1992-03-25
著者
-
鈴江 清吾
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
-
粟野 勝也
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd.
-
粟野 勝也
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
関連論文
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). III. 6,7-Dihydrodiol
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). II. Metabolites of Pyridine Ring
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). I. Metabolites of Alkyl Side Chains
- Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitoruy Activity on Platelet Aggregation. II
- Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitory Activity on Platelet Aggregation. I
- Studies on Hypoglycemic Agents. V. A New Synthetic Method for Sulfonylurea Derivatives