Studies on Hypoglycemic Agents. V. A New Synthetic Method for Sulfonylurea Derivatives

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概要

• 論文の詳細を見る

• p-Chloro (trifluoromethyl) phenyl or p-tolylsulfonylurea derivatives were prepared by the reaction of 2-arylsulfonylimino-1,3-oxathiolanes (III) with various amines. The oxathiolanes (III) were prepared by treatment of 2-hydroxyethyl N-arylsulfonyldithiocarbamate (II), which were obtained from sodium arylsulfonyliminodithiocarbonate and ethylene chlorohydrin, with ethyl chloroformate. The compounds (II) were also converted to N-arylsulfonylimino-1,3-dithiolanes (IV) by treating with sulfuric acid. The preparation of N-p-chlorophenylsulfonylimino-1,3-dioxolane (VII) was also described. Further 1-p-chlorophenylsulfonyl-2-thio-3-n-propylurea (IX) was obtained by treatment of IV (X=Cl) with n-propylamine.

• 社団法人日本薬学会の論文
• 1969-08-25

著者

• 鈴江 清吾

  Kyorin Chemical Laboratory

• 鈴江 清吾

  Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.

• 八倉 勉

  Kyorin Chemical Laboratory

関連論文

• Studies on Hepatic Agents. I. Synthesis of Aminoacyl (and Hydroxyacyl) Aminoacetonitriles
• Studies on Hypoglycemic Agents. IV. Synthesis of 1,4,3-Benzoxathiazine-4,4-dioxides
• Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). III. 6,7-Dihydrodiol
• Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). II. Metabolites of Pyridine Ring
• Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). I. Metabolites of Alkyl Side Chains
• Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitoruy Activity on Platelet Aggregation. II
• Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitory Activity on Platelet Aggregation. I
• Studies on Hypoglycemic Agents. V. A New Synthetic Method for Sulfonylurea Derivatives

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