Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitory Activity on Platelet Aggregation. I
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概要
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3-Nicotinoylpyrazolo[1,5-a]pyridines were synthesized by the raation of 3-unsubstituted pyrazolo[1,5-a]pyridines with nicotinoyl chloride hydrochloride. Tetrahydronicotinoyl derivatives were obtained by hydrogenation of the nicotinoyl derivatives. Furthermore, N-substituted derivatives were synthesized by the reaction of the tetrahydronicotinoyl derivatives with alkylating regents or isocyanates. These pyrazolo[1,5-a]pyridines were tested for inhibitory activity on arachidonic acid induced platelet aggregation in vitro and ex vivo. Some of these compounds showed higher inhibitory activity than aspirin. Among them, 2-methyl-3-(1,4,5,6-tetrahydronicotinoyl)pyrazolo[1,5-a]pyridine was found to be the most active compound.
- 社団法人日本薬学会の論文
- 1986-07-25
著者
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鈴江 清吾
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
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粟野 勝也
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd.
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瀬川 満
Central Research Laboratories, Kyorin Pharamaceutical Co., Ltd.,
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粟野 勝也
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
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瀬川 満
Central Research Laboratories Kyorin Pharamaceutical Co. Ltd.
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- Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitoruy Activity on Platelet Aggregation. II
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