Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitoruy Activity on Platelet Aggregation. II
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概要
- 論文の詳細を見る
The structure-activity relationship of 3-(p-substituted benzoyl)pyrazolo[1,5-a]pyridine derivatives as inhibitors of rabbit platelet aggregation in vitro have been examined. The cluster analysis approach to hte selection of substituents on the phenyl ring of 2-isopropyl-3-(p-substituted benzoyl)pyrazolo[1,5-a]pyridine was used, and the effect of substituents was investigated by quantitative regression analysis. The p-dimethylamino group was found to be the most effective p-substituent on the phenyl ring for antiaggregant activity.
- 社団法人日本薬学会の論文
- 1986-07-25
著者
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鈴江 清吾
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
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粟野 勝也
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd.
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粟野 勝也
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
関連論文
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). III. 6,7-Dihydrodiol
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). II. Metabolites of Pyridine Ring
- Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). I. Metabolites of Alkyl Side Chains
- Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitoruy Activity on Platelet Aggregation. II
- Synthesis of 3-Substituted Pyrazolo[1,5-a]pyridine Derivatives with Inhibitory Activity on Platelet Aggregation. I
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