Synthesis of Metabolites and Related Compounds of 3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (Ibudilast). I. Metabolites of Alkyl Side Chains
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概要
- 論文の詳細を見る
3-Isobutyryl-2-isopropylpyrazolo[1,5-α]pyridine (ibudilast) has a large number of metabolites. In order to unequivocally establish the true identity of these metabolites, we prepared a series of authentic reference compounds, namely novel pyrazolo[1,5-α]pyridine derivatives with mono- and dihydroxylated alkyl side chains and carboxylated alkyl side chains. These results lead to the conclusion that reactions at the 3-position of pyrazolo[1,5-α]pyridine are governed by the electron-donating effect and the weak basicity of bridge-head nitrogen. On the basis of these results we were able to establish a method of functional group introduction to the alkyl side chains of pyrazolo[1,5-α]pyridine.
- 社団法人日本薬学会の論文
- 1992-03-25
著者
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鈴江 清吾
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
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粟野 勝也
Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd.
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粟野 勝也
Central Reseasrch Laboratories Kyorin Pharmaceutical Co. Ltd.
関連論文
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