Participation of Lipid Peroxidation in Rat Pertussis Vaccine Pleurisy. III. Thiobarbituric Acid (TBA) Reactant and Lysosomal Enzyme

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Activity of lysosomal enzymes, such as N-acetyl-β-D-glucosaminidase (NAG), was assayed in exudate on a rat model of Bordetella pertussis vaccine pleurisy. Thiobarbituric acid (TBA)-reactive substance (TBA・R) and superoxide dismutase (SOD) activity were then monitored in the exudate on the acute phase response in this inflammatory model.Retention of the exudate in the pleural space increased rapidly after the challenge, and the exudate volume at 24 h reached about three times the volume at 6 h.The activity of NAG showed high levels at 6 h after the challenge, and then increased slightly at 24 h. This activity correlated with the retention of exudate and TBA・R levels.The activity of SOD at 6 h was shown to be higher than that at 24 h after the challenge, thus showing negative correlations with TBA・R levels and exudate volume. The levels of TBA・R rapidly increased and reached maximum values at 24 h. It was concluded that the above three parameters correlate to the acute phase response in this inflammatory model.
社団法人日本薬学会の論文
1991-02-25