Release of Nicotinamide from Fatty Acid-Nicotinamide Equimolar Complexes

概要

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The release behavior of nicotinamide (NAA) from fatty acid (FA)-NAA equimolar complexes was examined in a JP XI dissolution test apparatus in JP XI disintegration test medium No. 1 (pH 1.2) at 37℃ where the carbon number of FA is 14-18. The time required for 50% or 80% of NAA to release (T_<50> or T_<80>) was measured, and the effect of the constituent FA on T_<50> or T_<80> was investigated. The values of T_<50> or T_<80> for FA-NAA formed with odd-numberd FA were larger than those for FA-NAA formed with even-numbered FA whose alkyl chain length is one more carbon number longer, though the values of T_<50> of T_<80> increased rather regularly with an increase of the alkyl chain length for only even-numbered or odd-numbered FA. The values of T_<50> and T_<80> for FA-NAA formed with heptadecanoic acid (C17-NAA) were about 36 and 102 min, respectively, suggesting that C17-NAA may be applicable to the preparetion of a sustained-release drug formulation.
公益社団法人日本薬学会の論文
1991-11-25