Release Kinetics of Nicotinamide from Fatty Acid-Nicotinamide Equimolar Complexes. I. Release Characteristics of Fatty Acid Complexes

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The rates of release of nicotinamide (NAA) from fatty acid (FA)-NAA complexes, FA-NAA, were determined in a JP XI dissolution test apparatus in 500 ml of JP XI disintegration test medium No. 1 at 37℃. The release rate constant (k) and the activation Gibbs energy (ΔG^〓) for the release of NAA from FA-NAA were estimated. The results obtained for FA-NAA were compared with previous results obtained for the thiamine disulfide (TDS) complex, (FA)_6-(TDS).The plots of log k against the carbon number of the constituent FA (n) presented a zig-zag line which indicates a downward convex at an odd-numbered position. The plots of ΔG^〓 against n showed a zig-zag line with an upward convex at an odd-numbered position, though the positive value of ΔG^〓 increased rather regularly with an increase of n for either even-numbered or odd-numbered FA.The phonomena that the plots of log k vs. n and ΔG^〓 vs. show zig-zag lines due to the difference between even- and odd-numbered FA were the same as observed previously for the relase of TDS from (FA)_6 (TDS).
公益社団法人日本薬学会の論文
1991-10-25