The Effects of New Cytochalasins from Phomopsis sp. and the Derivatives on Cellular Structure and Actin Polymerization

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概要

• 論文の詳細を見る

• The effects of ten 10-phenyl-[11]cytochalasans produced by Phomopsis sp. including novel compounds haing 5,7-or 6,7-glycol structures and their derivatives, on the cell morphology and actin distribution in C3H-2K cells, as well as on lymphocyte capping and actin polymerization, were examined. The structure-activity relationship reported in the previous papars has been confirmed. The novel glycol type compounds showed little or no activity, suggesting the importance of the perhydroisoindol-1-one nucleus for the manifestation of the cytochalasin actions.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 飯田 和子

  (財)東京都臨床医学総合研究所細胞生物学研究部門

• 矢原 一郎

  (財)東京都臨床医学総合研究所細胞生物学研究部門

• 広瀬 隆

  Meiji College of Pharmacy

• 伊沢 慶彦

  Meiji College of Pharmacy

• 小山 清隆

  Meiji College of Pharmacy

• 名取 信策

  Meiji College of Pharmacy

• 飯田 和子

  The Tokyo Metropolitan Institute of Medical Science

• 矢原 一郎

  The Tokyo Metropolitan Institute of Medical Science

• 島岡 信

  Department of Biology, Facultyof Science, Chiba University

• 丸山 工作

  Department of Biology, Facultyof Science, Chiba University

• 島岡 信

  Department Of Biology Facultyof Science Chiba University

• 丸山 工作

  Department Of Biology Facultyof Science Chiba University

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