Effects of Phosphatidylcholines Containing Furan Fatty Acid on Oxidation in Multilamellar Liposomes

概要

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Several phosphatidylcholines (PCs) containing furan fatty acid (10,13-epoxy-11,12-dimethyloctadeca-10,12-dienoic acid, F acid) were synthesized, and their antioxidant activities were studied in the oxidation of soybean PC. The rate of oxidation in soybean PC liposomes initiated with 2,2'-azobis(2,4-dimethylvaleronitrile) (AMVN), a lipophilic azoinitiator, was measured by following the oxygen uptake, the accumulation of conjugated diene, and the disappearance of unsaturated fatty acid moieties. These PCs containing F acid were found to retard the rate of oxidation in soybean PC liposomes, and the retarding effect increased in the following order : 1/2 mol of di-furanoacyl PC (di-F PC)<1 mol of 1-furanoacyl-2-linoleoyl PC (F-18 : 2 PC)<1 mol of 1-furanoacyl-2-arachidonyl PC (F-20 : 4 PC)<1 mol of di-F PC (1 : 1 : 1 : 2,as molar ratios of F acid residue). This is the first report showing that the naturally occurring F acid has a retarding effect on lipid peroxidation.
社団法人日本薬学会の論文
1989-05-25