Fenton系により産生するヒドロキシルラジカルに対するフラン誘導体の捕捉能に関する研究

概要

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As the continuation of the work on the antioxidant properties of furan derivatives, we have studied hydroxyl radical (OH・) scavenging activity of dimethylfuran (DMF) and diphenylfuran (DPF), which are well-known as an effective scavenger of singlet oxygen, by an ESR spin trapping technique. The incubation mixture of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as a spin trapping agent with Fe<2+> and H_2O_2 in 50% acetonitrile aqueous solution gave 1 : 2 : 2 : 1 line signals characteristic of DMPO-OH spin adduct. The additions of furan derivatives to the incubation mixture decreased the intensity of the DMPO-OH spin adduct signal in a dose-dependent manner. The activities of furan derivatives were in the order of DMF > DPF > furan. The decrease in the intensity of the signals was not due to the inhibition of OH・ generating system itself and the destruction of the spin adduct by furan derivatives. By comparison with the common OH・ scavengers, DMF and DPF were found to scavenge OH・ more effectively than dimethylsulfoxide and mannitol. These results indicate that DMF and DPF can act as a OH・ scavenger as well as a singlet oxygen scavenger.
社団法人日本薬学会の論文
1998-06-01