Synthesis and α-Glucosidase-Inhibiting Activity of a New α-Glucosidase Inhibitor, 4-O-α-D-Glucopyranosylmoranoline and Its N-Substituted Derivatives

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Various N-substituted derivatives of 4-O-α-D-glucopyranosylmoranoline have been synthesized, and their inhibitory activities against rabbit sucrase and maltase have been measured, as well as their effects on postprandial hyperglycemia in the sucrose-loaded rat, 4-O-α-D-Glucopyranosylmoranoline was also shown to have potent hypoglycemic activity in starch-loaded dogs.
社団法人日本薬学会の論文
1989-01-25