Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. III. Mechanism of 8-Hydroxyquinoline in Activating the Aerobic Reduction of Cytochrome c.

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概要

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• 1. In the presence of 8-hydroxyquinoline the reduction of cytochrome c by xanthine oxidase was markedly accelerated by H_2O_2 under both aerobic and anaerobic conditions. 2. The accelerating effect of H_2O_2 was induced only when H_2O_2 was preincubated with 8-hydroxyquinoline and cytochrome c, and this effect was dependent on the concentration of each component and on the period of preincubation time. 3. Thin-layer chromatography showed that 5,8-dihydroxyquinoline and 5,8-quinolinedione were present both in aerobically incubated medium containing hypoxanthine, xanthine oxidase, cytochrome c and 8-hydroxyquinoline and in aerobically or anaerobically incubated medium containing cytochrome c, 8-hydroxyquinoline and H_2O_2. These two quinoline derivatives were proved to be potent electron carriers between xanthine oxidase and cytochrome c. 4. As a plausible explanation for the mechanism of action of 8-hydroxyquinoline in inhibiting the reoxidation and in accelerating the reduction of cytochrome c, it was proposed that 8-hydroxyquinoline is hydroxylated to 5,8-dihydroxyquinoline by the peroxidative action of cytochrome c, and this reaction product acts as an electron carrier which promotes the anaerobic type of reduction of cytochrome c.

• 公益社団法人日本薬学会の論文
• 1967-10-25

著者

• 榎本 宏

  Research Laboratories, Nippon Shinyaku Co., Ltd.,

• 榎本 宏

  Research Laboratories Nippon Shinyaku Co. Ltd.

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• Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. II. Prevention of Reoxidation of Reduced Cytochrome c by 8-Hydroxyquinoline and m-Phenylenediamine.
• Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. III. Mechanism of 8-Hydroxyquinoline in Activating the Aerobic Reduction of Cytochrome c.
• Aerobic reduction of cytochrome c preparation by xanthine oxidase-2,3-

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