Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. II. Prevention of Reoxidation of Reduced Cytochrome c by 8-Hydroxyquinoline and m-Phenylenediamine.

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概要

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• 1. A study was made of 42 substances, including catalase, metal chelating agents and peroxidase substrates as to their effects on the over-all course of aerobic reduction of cytochrome c by xanthine oxidase. 2. It was found that 8-hydroxyquinoline and m-phenylenediamine completely prevented the reoxidation of reduced cytochrome c in concentrations above 3.3×10^<-5> and 1.7×10^<-5> M, respectively. A similar, but less marked, effect was obtained with small amounts of catalase and KCN. 3. This enabled the determination of enzymically reducible cytochrome c except polymeric or CO-sensitive cytochrome c included in the preparation, by xanthine oxidase, with the use of 8-hydroxyquinoline and m-phenylenediamine. 4. 8-Hydroxyquinoline and m-phenylenediamine had an inhibitory effect on the peroxidase activity of cytochrome c.

• 公益社団法人日本薬学会の論文
• 1967-10-25

著者

• 山口 威

  Research Laboratory Nippon Shinyaku Co. Ltd.

• 榎本 宏

  Research Laboratories, Nippon Shinyaku Co., Ltd.,

• 榎本 宏

  Research Laboratories Nippon Shinyaku Co. Ltd.

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• Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. II. Prevention of Reoxidation of Reduced Cytochrome c by 8-Hydroxyquinoline and m-Phenylenediamine.
• Aerobic Reduction of Cytochrome c Preparation by Xanthine Oxidase. III. Mechanism of 8-Hydroxyquinoline in Activating the Aerobic Reduction of Cytochrome c.
• Aerobic reduction of cytochrome c preparation by xanthine oxidase-2,3-

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