Distribution of Aminopeptidases in Various Nephron Segments Isolated from Rat Kidney
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概要
- 論文の詳細を見る
The present study was undertaken to investigate the activities of aminopeptidases which were reported to degrade physiologically active peptides including angiotensins, vasopressin, oxytocin and so on, in various nephron segments isolated from the rat kidney. These peptidases include leucine aminopeptidase-, aminopeptidase A-, angiotensinase A- and cystine aminopeptidase-like enzymes. The activities of these peptidases were found to be higher in the proximal tubule than in other segments. In the proximal tubule, these peptidases showed their highest activities in the pars recta. The activities of aminopeptidase A- and angiotensinase A-like enzyme (s) were also high in the glomerulus. In contrast, the activities of these peptidases were hardly detectable in distally located nephron segments. From this distribution of the peptidases, we speculate that the above physiologically active peptides are metabolized in the proximal tubule, particularly in the pars recta, and that angiotensins are metabolized in the glomerulus in addition to the proximal tubule.
- 公益社団法人日本薬学会の論文
- 1984-08-25
著者
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須藤 純一
東日本学園大学薬学部毒理学教室
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田辺 恒義
Department of Toxicology, Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University
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田辺 恒義
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Higashi Nippon Gakuen University
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田辺 恒義
Department Of Toxicology Faculty Of Pharmaceutical Sciences Higashi-nippon-gakuen University
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