New Platelet Aggregation Inhibitors from Tan-Shen ; Radix of Salvia miltiorrhiza BUNGE
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概要
- 論文の詳細を見る
A potent inhibitor (Ro 09-0680) of rabbit platelet aggregation induced by collagen was isolated from a Chinese medicine, Tan-Shen, (radix of Salvia miltiorrhiza) and identified as a novel component, 2-isopropyl-8-methylphenanthrene-3,4-dione (I). IC_<50> of I in the previously established assay was 6.6×10^<-6>M, which is 30 times more potent than papaverine. Related diketophenanthrene derivatives such as tanshinone I, tanshinone II and cryptotanshinone were also found to have the inhibitory activity, though to lesser extents.
- 社団法人日本薬学会の論文
- 1983-05-25
著者
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藤生 守男
日本ロシュ研
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鬼塚 光子
Department of Microbiology and Chemotherapy, Nippon Roche Research Center
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藤生 守男
Department of Microbiology and Chemotherapy, Nippon Roche Research Center
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新間 信夫
Department of Microbiology and Chemotherapy, Nippon Roche Research Center
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丸山 博巳
Department of Microbiology and Chemotherapy, Nippon Roche Research Center
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丸山 博巳
Department Of Microbiology And Chemotherapy Nippon Roche Research Center
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新間 信夫
Department Of Microbiology And Chemotherapy Nippon Roche Research Center
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鬼塚 光子
Department Of Microbiology And Chemotherapy Nippon Roche Research Center
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藤生 守男
Department Of Microbiology And Chemotherapy Nippon Roche Research Center
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