L-β-(5-Hydroxy-2-pyridyl)-alanine and L-β-(3-Hydroxyureido)-alanine from Streptomyces
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概要
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In the course of the chemical screening study on the metabolites from actinomycetes, two unusual amino acids were isolated : L-β-(5-Hydroxy-2-pyridyl)-alanine (1) and L-β-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester (2) were antagonized by L-tyrosine, and those of 9 and its derivative (17) by L-glutamine.
- 社団法人日本薬学会の論文
- 1975-11-25
著者
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庄村 喬
Central Research Laboratories Meiji Seika Kaisha Ltd.
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井上 重治
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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仁井田 太郎
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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渡辺 浩
Central Research Laboratories Meiji Seika Kaisha Ltd.
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古田 順子
Central Research Laboratories Meiji Seika Kaisha Ltd.
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近藤 嘉和
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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小川 安昭
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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仁井田 太郎
Central Research Laboratories Meiji Seika Kaisha Ltd.
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近藤 嘉和
Central Research Laboratories Meiji Seika Kaisha Ltd.
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井上 重治
Central Research Laboratories Meiji Seika Kaisha Ltd.
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小川 安昭
Central Research Laboratories Meiji Seika Kaisha Ltd.
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- L-β-(5-Hydroxy-2-pyridyl)-alanine and L-β-(3-Hydroxyureido)-alanine from Streptomyces
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