Chemical Modification of Kanamycin. III. Syntheses of 6-Amino-6-deoxy-2-manno-kanamycin and 6-Hydrazino-6-deoxy-2-manno-kanamycin.
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概要
- 論文の詳細を見る
Syntheses of the title compounds starting from 2,6-di-O-p-tolylsulfonyl-tetra-N-acetyl-kanamycin via 6-azido-and 6-hydrazino-2,3-oxazolinum intermediates. Terminal amination and configurational inversion at C_2 of the 3-amino-glucose moiety were confirmed by nuclear magnetic resonance spectroscopy, molecular rotations and hydrolysis data. The structures of two diamino-derivatives of tetra-N-acetyl-kanamycin obtained as minor products were discussed.
- 公益社団法人日本薬学会の論文
- 1967-12-25
著者
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井上 重治
Central Research Laboratories, Meiji Seika Kaisha, Ltd.
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井上 重治
Central Research Laboratories Meiji Seika Kaisha Ltd.
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