Effect of Radix Ginseng Extract on Cytoplasmic Polysome in Rat Liver

概要

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It was shown that a single intraperitoneal injection of extract (fraction 4) from roots of Panax ginseng C. A. Meyer, increased the incorporation rate of labeled precursor into cytoplasmic polysomal ribonucleic acid (RNA) of rat liver. The content of heavy polysomes (over hexamer) in postmitochondrial supernatant from liver treated with fraction 4 was observed to increase at 6 and 10 hr after treatment. Sedimentation analysis of ribosomal RNA and messenger RNA derived from polysomes showed that the newly induced RNA by fraction 4 is evenly distributed over all RNA. Particularly, 29S ribosomal and 9-10S messenger RNAs were stimulated significantly. In an amino acid incorporation system in vitro, stimulatory activities of microsomes and polysomes from treated rat liver are more active by 85 and 67% than those from normal liver, respectively.
社団法人日本薬学会の論文
1972-02-25