Studies on Food Additives. X. The Metabolism of p-Ethoxyphenylurea in the Rabbit
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概要
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1. The metabolic fate of p-ethoxyphenylurea in the rabbit was studied. 2. About 40% of the dose was excreted as phenolic substances, presumably p-hydroxyphenylurea. The phenolic products were excreted as the unconjugated (7%), glucuronide (11%), and sulfate (23% of p-ethoxyphenylurea fed). p-Hydroxyphenylurea was isolated as its diacetyl dericative. The sulfate and glucuronide of p-hydroxyphenylurea were detected. 3. It was suggested that the main glucuronide of p-ethoxyphenylurea was N-glucuronide. This compound accounted for about 27% of p-ethoxyphenylurea fed. The N-glucuronide was isolated as crystals of both potassium and ammonium salts of p-ethoxyphenylurea N-glucuronide. 4. About 3% of the dose was excreted unchanged.
- 社団法人日本薬学会の論文
- 1966-01-25
著者
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青木 勇
Faculty Of Pharmaceutical Sciences Hokkaido University
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植松 孝悦
Faculty Of Pharmaceutical Sciences Hokkaido University
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赤木 満州雄
Faculty of Pharmaceutical Sciences, Hokkaido University
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赤木 満州雄
Faculty Of Pharmaceutical Sciences Hokkaido University
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赤木 満州雄
Faculty of Pharmaceutical Science, School of Medicine, Hokkaido University
関連論文
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- Studies on Food Additives. XI. N-Glucosiduronate Formation of Arylurea in vivo and in vitro
- Studies on Food Additives. X. The Metabolism of p-Ethoxyphenylurea in the Rabbit
- Studies on Food Additives. IX. Estimation of p-Ethoxyphenylurea in Biological Materials and Physiological Disposition in the Animals
- Structure of p-Ethoxyphenylurea-N-glucuronide
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- Studies on Food Additives. VIII. Metabolism of α-Hydroxy-2,6-di-tert-butyl-p-cresol. Isolation of Metabolites.
- Studies on Food Additives. VI. Metabolism of 2,6-Di-tert-butyl-p-cresol (BHT) in a Rabbit. (1). Determination and Paper Chromatography of a Metabolite.
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