Syntheses of β-Carboline Derivatives. II. Pentacyclic β-Carboline Analogs of Alstoniline and Tetrahydrobenzindoloquinolizines.
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概要
- 論文の詳細を見る
The synthesis of β-carboline derivative reported in the preceding paper was now successfully extended to include the syntheses of two new salts of pentacyclic β-carbolinium derivatives (III and IV), which formed the anhydronium bases (XXVIII and XXIX) by the agency of alkali. The reduction of (III) to the corresponding tetrahydro base (XXXVII) was only possible with sodium borohydride, directly followed by catalytic reduction over Raney nickel catalyst, while the tetrahydro base (XXXVIII) of (IV) could be obtained with an excess of sodium borohydride in boiling hydrous ethanol in one step. The stability of (XXXVII) and (XXXVIII) in the air was compared with that of tetrahydrodibenzo-quinolizines.
- 社団法人日本薬学会の論文
- 1959-06-10
著者
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菅澤 重彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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菅澤 重彦
Faculty of Pharmaceutical Sciences, University of Tokyo
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高野 誠一
Pharmaceutical Institute Tohoku University
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高野 誠一
Faculty of Pharmaceutical Sciences, University of Tokyo
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菅澤 重彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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