Synthesis of β-Carboline Derivatives. III. A Synthesis of Dimethoxybenzindoloquinolizine.
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概要
- 論文の詳細を見る
A new method for synthsis of β-carboline derivatives reported in the previous papers was now extended to include the preparation of tetrahydrobenzindoloquinolizine derivative (XIII). Thus, N-(3,4-dimethoxyphenethyl)-2-indoleacetamide was cyclized by Bischler-Napieralski-Perkin method to yield the corresponding 3,4-dihydroisoquinoline. The latter, after being dehydrogenated, was condensed with formaldehyde and diethylamine to give the gramine-type compound (V), from which benzindoloquinolizinium base (XII) was prepared as previously. Reduction of the latter to (XIII) was effected either catalytically or by means of sodium borohydride.
- 公益社団法人日本薬学会の論文
- 1960-10-25
著者
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菅澤 重彦
Organic Chemistry Research Laboratory, Tanabe Seiyaku Co., Ltd.
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菅澤 重彦
Faculty of Pharmaceutical Sciences, University of Tokyo
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出口 義雄
Faculty Of Pharmaceutical Sciences University Of Tokyo
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菅澤 重彦
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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